HGH Fragment 176-191 (6mg)

1. Lowers Blood Sugar

Research in animals has revealed that the c-terminal end of hGH is primarily responsible for the protein’s hypoglycemic (lowering blood sugar) effects. Testing of at least six different fragments derived from this section of hGH has shown that fragment 176-191 is the most effective synthetic derivative of hGH for lowering blood sugar levels. This effect is secondary to a sustained increase in plasma insulin levels[1]. There is some interest in using fragment 176-191 as a treatment for both prediabetes and type 2 diabetes.

2. Fat Burning And Weight Loss

Fragment 176-191 has earned the nickname of “lipolytic fragment” because testing in mice has revealed the peptide to have substantial fat burning and weight loss properties. It is thought that this action is mediated through an increase in production of beta-3 adrenergic receptors (B3-AR or ADRB3)[2]. Agonist action at ADRB3 is known to directly increase fat burning in adipose tissue and is also responsible for thermogenesis in skeletal muscle[3]. Mice that have been genetically modified to produce no ADRB3 do not respond to the lipolytic effects of hGH or fragment 176-191[2].
Studies show that the increased fat burning associated with fragment 176-191 directly correlates with energy expenditure and thus weight reduction, leading to a nearly 50% reduction in weight gain in obese animals over a three-week course[4]. Interestingly, the weight loss effects were seen only in obese mice, with lean mice maintaining normal body weight, on average, even when exposed to fragment 176-191[2]. These findings indicate that there are secondary regulatory pathways for lipolysis that override ADRB3 function when body weight is at or near ideal, opening up areas for additional research into energy homeostasis.

3. Promotes Cartilage Regeneration

Though fragment 176-191 is primarily of interest for its lipolytic properties, the peptide is under investigation for other possible benefits. Of note, a 2015 article out of Korea revealed that fragment 176-191 may be able to potentiate the effects of hyaluronic acid injections in promoting cartilage regeneration. Studies in rabbits indicated that weekly injections of fragment 176-191 increase laboratory measures of cartilage growth and that co-administration of the peptide with hyaluronic acid (HA) produces even more substantial effects. Similarly, the study found that fragment 176-191, both alone and in combination with HA, reduces disability associated with osteoarthritis. There is hope that this may lead to advanced therapies for osteoarthritis and may even eliminate the need for surgery in certain settings[7].

4. Safety Studies

Multi-drug resistance is becoming increasingly common in a number of infections, rendering current therapy ineffective. UnforThere is some concern that the use of hGH or its derivatives for weight control may have unwanted side effects. This concern arises from the fact that studies of hGH have shown that long-term exogenous administration, while increasing lean body mass and decreasing adipose tissue, can also cause:
⚫ increased insulin resistance,
⚫ diabetes,
⚫ acromegaly,
⚫ cancer,
⚫ hypertension (high blood pressure), and
⚫ edema (swelling).
In 2013, a study published in the Journal of Endocrinology and Metabolism evaluated six studies of fragment 176-191 to assess the rate and significance of negative effects associated with the peptide. The study, included only research that followed the randomized, double-blinded, placebo-controlled model of a phase IIb clinical trial in order to keep the highest possible standards of evidence. It found that IV and oral administration of Fragment 176-191, when compared to placebo, led to no changes in:tunately, there are very few new antibiotics in the pipeline and the process of drug development can take upwards of twenty years on average. A recent study on the effects of TB-4 and its adjuvants, however, provides some hope. Studies of mice suffering from a Pseudomonas aeruginosa infection of the eye have found that TB-4 combined with ciprofloxacin, a standard antibiotic for treating Pseudomonas
aeruginosa, increases the effects of the antibiotic, improves healing, reduces inflammation, and promotes faster recovery. The results of just five days of combined therapy showed decreased numbers of colony-forming units (CFUs), decreased neutrophil (a type of white blood cell) count, and decreased levels of inflammatory reactive oxygen species[$]. This is the first study to demonstrate that TB-500 and similar peptides might be used to promote and enhance the effects of antibiotics.

⚫ physical findings,
⚫ laboratory parameters,
⚫ glucose levels,
⚫ glucose tolerance,
⚫ insulin sensitivity,
⚫ IGF-1 levels, or
⚫ rates of adverse events (e.g. headache)[*], [$].
The results of this meta-analysis suggest that fragment 176-191 offers many of the benefits of hGH without the associated negative (and often serious) side effects. These findings further the argument for pursuing regulatory approval for use of fragment 176-191 in the clinical setting, but also offer insight into the regulation of human growth, fat deposition, and energy homeostasis. These findings make it clear that it is possible to target fat loss without affecting energy homeostasis in other nutrient pathways, opening the door for a deeper exploration of human energy regulation and methods of manipulating it.

5. Future Research

The primary area of research for fragment 176-191 is in weight loss and lipolysis where significant effort is being expended to learn how the peptide can be used to understand fat metabolism and energy homeostasis. The most active secondary area of research is in connective tissue regeneration, particularly cartilage repair.

6. TB-500 and Neurodegenerative Diseases

Progress in finding a treatment for neurodegenerative diseases like Alzheimer’s and prion disease has been slow at best. A recent study into the effects of TB-4 on the ability of the immune system to deal with prion protein has shown that the peptide enhances autophagy[*]. Autophagy is the central nervous system’s primary protective mechanism against neurodegenerative diseases. The ability of TB-4 to enhance this natural immunity is the first progression toward real treatment of these debilitating diseases in a long time.

7. TB-500 Has Wide Application

TB-500 due to its fundamental role in cell structure and function can affect a number of different body tissues. This has resulted in a wide and varied field of research into the effects of this peptide. From treating heart and neurological disease to enhancing the effects of antibiotics, TB-500 is one of the hottest peptides in research today and will likely remain one of the most heavily investigated peptides for the foreseeable future.
TB-500 exhibits minimal side effects, low oral and excellent subcutaneous bioavailability in mice. Per kg dosage in mice does not scale to humans. TB-500 for sale at Peptide Sciences is limited to educational and scientific research only, not for human consumption. Only buy TB-500 if you are a licensed researcher.